Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise
Recruiting · NCT05025774 · Observational (researchers observe without assigning treatment) · Lead sponsor: Masonic Cancer Center, University of Minnesota
View the official record on ClinicalTrials.gov →Interventions studied
Physical activity
What this trial is about
This study aims to more accurately assess cardiac function, ventilation and exercise capacity in a non-invasive fashion, and to better characterize exercise intolerance in the setting of three populations of individuals with chronic diseases of childhood (acute lymphoblastic leukemia (ALL), chronic lung disease (CLD) of prematurity, and post-heart transplant (HT))
Who can take part
Age range
8 Years to 25 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Cases:
- Acute lymphoblastic leukemia survivor, OR living with chronic lung disease of prematurity, OR living with heart transplant
- 8-25 years old
- Height: ≥ 48 inches
- Ambulatory without assistance
- English speaking
- Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
- SpO2 \>92%
- Not pregnant
- ALL survivor specific: must have completed therapy ≥ 3 months prior to study entry
- Controls
- 8-25 years old
- Height: ≥ 48 inches
- Ambulatory without assistance
- English speaking
- No history of arrhythmia or known cardiac dysfunction at baseline
- Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
- SpO2 \>95%
- Not pregnant
Exclusion criteria
- Cases:
- ALL specific: received cranial radiation, bone marrow transplant recipients
- Investigator or patient's primary physician deems the patient unsuitable for the study
- Controls:
- History of malignancy, CLD or HT or any other diagnosis which may reduce cardiorespiratory function
- Investigator deems the patient unsuitable for the study
Where it is running
1 location listed across 1 US state.
- Masonic Cancer Center - Minneapolis, Minnesota, United States