Pencil Beam Proton Therapy for Recurrences in Anal Cancer Patients Previously Treated With Radiotherapy (DACG 5)
Recruiting · NCT05055635 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Aarhus
View the official record on ClinicalTrials.gov →Interventions studied
Pencil beam proton therapy
What this trial is about
This protocol aims to determine toxicity and efficacy of re-irradiation for patients with recurrences from anal cancers with dose-escalated pencil beam proton therapy either pre-operative for marginally resectable recurrences or as a definitive treatment strategy (un-resectable, operation declined etc.). The over-all aim is to improve local tumor control with acceptable side effects.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 2
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Recurrent anal cancer
- Bioptically verified (squamous cell carcinoma)
- Available dose plan from primary radiotherapy
- Previous RT (\>30Gy EQD2)
- Evaluated in MDT-conferences (Herlev, Aarhus)
- Age\>18 years
- PS 0-2
- Adequate organ function
- Written informed consent
Exclusion criteria
- Distant metastases deemed without curative intended treatment options (PET-CT)
- Unable to undergo MRI, PET-CT
- Inability to attend full course radiotherapy and follow up in the outpatient clinic.
Where it is running
1 location listed.
- Danish Centre for Particle Therapy - Aarhus N, Aarhus, Denmark