Preventing Cognitive Decline by Reducing BP Target Trial
Recruiting · NCT05106036 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Texas Southwestern Medical Center
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The PCOT study is a multi-site randomized trial of patients 70 years or older with high BP. The main goal of the study Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) is to conduct a large pragmatic clinical trial (PCT) to test the hypothesis that patients who receive care with a combination of clinical decision support (CDS) and team-based care delivered in primary care practices will have better blood pressure control and a lower incidence of mild cognitive impairment and dementia than patients receiving usual medical care. Patients will be recruited from UT Southwestern Medical Center and Parkland Health \& Hospital System.
Who can take part
Inclusion criteria
- High BP defined as at least 1 BP readings of SBP \>= 130 or DBP \>=80 during the 24 months prior to enrollment
- Clinic visit with primary care provider within the last 24 months
- Ability to write and speak English or Spanish
- 70 years of age or older
- Ability to understand and willingness to provide informed consent
- Owns a smartphone
Exclusion criteria
- Blood pressure consistently \<130/80 mmHg
- Presence of dementia, Alzheimer's disease, or significant neurological disease
- Major and unstable heart disease (e.g., acute heart failure (systolic or diastolic), acute on chronic heart failure (systolic or diastolic), acute coronary syndrome or cardiac arrest, liver or renal transplantation
- Under 70 years of age
- Inability to write or speak English or Spanish
- Chronic kidney disease stage 5 or ESKD
- Chemotherapy
- Any conditions judged by the medical providers to contraindicate participation due to risk to patient safety or lack of adherence
- Expected life expectancy under a year
Where it is running
1 location listed across 1 US state.
- UT Southwestern Medical Center - Dallas, Texas, United States