Exploration of the Cellular and Molecular Mechanisms in Patients Receiving Biotherapies Targeting the IL-23/IL-17 Axis in Cutaneous Psoriasis
Recruiting · NCT05111210 · Observational (researchers observe without assigning treatment) · Lead sponsor: Institut Pasteur
View the official record on ClinicalTrials.gov →Interventions studied
Blood sampleData collectionskin biopsies
What this trial is about
This is a research study involving humans, of the interventional type with minimal risks and constraints (RIPH2). It is a monocentric, non randomized prospective study aiming to better understand the mechanisms of the response to anti-IL-23 biologics in psoriasis patients attending the dermatology department of hospital Cochin (APHP).
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- All patients:
- Adults (\>18 years)
- Presenting with cutaneous psoriasis
- Patients have signed an informed consent
- Beneficiary of the health insurance, except for the AME Only for patients of Group 1
- Patients require systemic treatment for psoriasis
- Patients are naïve to biological therapies
- nly for patients of Group 2:
- Patients requiring treatment with anti-IL-23 biologics (guselkumab, risankizumab, tildrakizumab) upon referent physician's decision.
- Patients are naïve to biological therapies or have received only one biologic, with a "wash-out" period of at least 4 months
- Non inclusion Criteria:
- For all :
- Patient is minor
- Patient is pregnant or breastfeeding
- Patient is immunocompromised
- Patient is under legal protection, curatorship, guardianship
- Patient refuses consent
- Patient is unable to comply with study requirements for geographic, social or psychiatric reason.
- Beneficiary of the AME Only for patients of Group 1
- Patient has received biologics Only for patients of Group 2
- Patient has a contraindication to the chosen biotherapy
- Patient has received biologics within the last 4 months
- Patient has been treated with 2 or more biologics
- Patient has already received an anti-IL-23 biologic
Where it is running
1 location listed.
- Lars ROGGE - Paris, Île-de-France Region, France