Polysomnographic Titration of Non-invasive Ventilation in Motor Neurone Disease
Recruiting · NCT05136222 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Melbourne
View the official record on ClinicalTrials.gov →Interventions studied
Intervention polysomnographySham polysomnography
What this trial is about
A two-arm, individual participant randomised controlled, assessor-blinded trial in 7 MND care centres across Australia will be undertaken.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age \>18 years
- Clinical indication to commence long term NIV
- Confirmed clinical diagnosis of underlying condition
Exclusion criteria
- Medically unstable
- Hypoventilation attributable to medications with sedative/respiratory depressant side- effects
- Use of NIV for more than 1 month in the previous 3 months
- Inability to provide informed consent
- Previous intolerance of NIV
Where it is running
13 locations listed.
- Flinders Medical Centre - Adelaide, Australia
- The Prince Charles Hospital - Brisbane, Australia
- Motor Neurone Disease Australia - Canberra, Australia
- Austin Health - Melbourne, Australia
- Australian MND Registry - Melbourne, Australia
- FightMND - Melbourne, Australia
- Institute for Breathing and Sleep - Melbourne, Australia
- Monash University - Melbourne, Australia
- University of Melbourne - Melbourne, Australia
- Sir Charles Gairdner Hospital - Perth, Australia
- Macquarie University - Sydney, Australia
- Royal Prince Alfred Hospital - Sydney, Australia
- Westmead Hospital - Sydney, Australia