The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Training Regimens (CaRe BFR)
Recruiting · NCT05163600 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Zurich
View the official record on ClinicalTrials.gov →Interventions studied
BFR REsistance 48% vs. 80% LOPBFR Resistance 80% LOPBFR-CYC 3x2minBFR-CYC 50% peak / 50% AOP (exhaustive)
What this trial is about
The investigators hypothesize that BFR exercise regimens result in a different acute cardiorespiratory response pattern compared to traditional exercise regimens. Furthermore, the investigators hypothesize that these patterns differ between healthy participants and participants with COPD. Regarding secondary objective, the investigators hypothesize that BFR results in lower blood pressure responses compared to traditional exercise training in both healthy and COPD participants.
Who can take part
Age range
18 Years to 90 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age ≥ 18 years
- Clinically healthy
Exclusion criteria
- Physical or intellectual impairment precluding informed consent or protocol adherence
- Non-German speaking (precluding informed consent)
- Pain during exercise of any origin
- Pregnancy
- History of thromboembolic event in the lower extremity
- Resting systolic blood pressure \<100 mmHg
- Inclusion and exclusion for the COPD participants are defined by the following criteria.
- Inclusion criteria:
- Age ≥ 18 years
- Diagnosed COPD according to GOLD-guidelines12
- Exclusion criteria:
- Physical or intellectual impairment precluding informed consent or protocol adherence
- Non-German speaking (precluding informed consent)
- Acute or recent (within the last 6 weeks) exacerbation of COPD
- Pain during exercise of any origin
- Pregnancy
- History of thromboembolic event in the lower extremity
- Resting systolic blood pressure \<100 mmHg
Where it is running
1 location listed.
- University Hospital Zürich - Zurich, Canton of Zurich, Switzerland