Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis
Recruiting · NCT05177523 · Observational (researchers observe without assigning treatment) · Lead sponsor: University Hospital, Basel, Switzerland
View the official record on ClinicalTrials.gov →Interventions studied
MRINeurocognitive examination for healthy subjectsblood sampling
What this trial is about
This project is to: 1. Quantify differences in axonal integrity and organization in aMS versus naPMS patients. 2. Quantify changes in axonal integrity and organization in aMS versus naPMS patients over a two-year period. 3. Validate the combination of imaging parameters that best differentiate aMS versus naPMS patients using histopathology.
Who can take part
Age range
18 Years to 80 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- for patients:
- Patients may be diagnosed with:
- active RRMS (n=100): Relapsing-remitting course and \> 1 clinical relapse and/or signs of MRI activity (\> 1 Gd enhancing lesion) during the last year before study enrollment.
- non-active PMS (n=100): Progressive course (PPMS or SPMS) and no clinical relapses and/or signs of MRI activity during the last year before study enrollment.
- Age 18-80 years old
- No other neurological or psychiatric disorder
- Inclusion criteria for healthy controls:
- Age 18-80 years old
- No other neurological or psychiatric disorder
Exclusion criteria
- for patients and healthy controls:
- Pregnancy
- Contraindication to MRI (eg, claustrophobia, metallic implants, pacemaker etc).
- Inability to give consent
Where it is running
1 location listed.
- University Hospital Basel, Department of Neurology - Basel, Switzerland