Sleep and Circadian Mechanisms in Hypertension
Recruiting · NCT05184933 · Interventional (participants receive a specific treatment) · Lead sponsor: Oregon Health and Science University
View the official record on ClinicalTrials.gov →Interventions studied
At-home PolysomnographyCircadian ProtocolOvernight Sleep TrialRegularized Sleep ScheduleRested Wakefulness Trial
What this trial is about
This study is a mechanistic clinical trial designed to investigate the effects of the circadian system and sleep on non-dipping blood pressure (BP) in people with hypertension (HTN).
Who can take part
Age range
25 Years to 64 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Ages 25-64
- BMI 18.5-42kg/m2
- Hypertension (average resting blood pressure between 130/80 mmHg and 160/100 mmHg)
Exclusion criteria
- Over 5 pack-years of smoking;
- Prior shift work within 12 months prior to the study;
- Travel greater than three time zones for at least 3 months;
- History of heart failure, cardiomyopathy, or history of bypass surgery, angioplasty, or previous myocardial infarction;
- Acute or chronic diseases (except hypertension) that may affect outcome measures;
- History of psychological conditions;
- Sleep disorders, like severe sleep apnea, insomnia, etc.;
- Prescription medications (Contraceptives and anti-hypertensive medications are permissible);
- History of Illicit drug use and alcohol dependency;
- 30 days free of cannabis use prior to the study;
- Pregnancy;
- Upper cut-off of 160/100 mmHg for BP
Where it is running
1 location listed across 1 US state.
- Oregon Health and Science University - Portland, Oregon, United States