Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
Recruiting · NCT05219799 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Missouri-Columbia
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.
Who can take part
Age range
18 Years to 45 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Early Phase 1
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- BMI \>18 kg/m2
Exclusion criteria
- Pregnancy, breastfeeding
- Diagnosed sleep apnea or AHI \>10 events/hr
- Current smoking/Nicotine use
- Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
- Nerve/neurologic disease
- Cardiovascular, hepatic, renal, respiratory disease
- Blood pressure ≥140/90 mmHg
- Diabetes, Polycystic ovarian syndrome
- Communication barriers
- Prescription medications, Sensitivity to lidocaine
Where it is running
1 location listed across 1 US state.
- University of Missouri - Columbia, Missouri, United States