Fexofenadine in Patients With Active Rheumatoid Arthritis
Recruiting · NCT05264025 · Interventional (participants receive a specific treatment) · Lead sponsor: October 6 University
View the official record on ClinicalTrials.gov →Interventions studied
FexofenadinePlacebo
What this trial is about
Rheumatoid arthritis (RA) is an inflammatory autoimmune polyarthritis affecting ∼1% of the world population, resulting in the loss of joint function and progressive structural damage in affected joints. Fexofenadine has been widely used to treat various allergic diseases, like allergic rhinitis, conjunctivitis and chronic idiopathic urticaria. the molecular mechanisms underlying fexofenadine mediated inhibition of TNF-α signalling
Who can take part
Age range
18 Years to 60 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Phase 1, Phase 2
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Moderate to severe RA (disease activity score-28 joints: DAS-28 \> 3.2) were recruited.
- Age between 18 - 60 years having active disease according to the diagnosis of an experienced rheumatologist, being under treatment with disease-modifying anti-rheumatic drugs (DMARDs), not receiving cytokine inhibitors
- Signing informed consent and willingness of the participant to accept randomization to any assigned treatment arm.
Exclusion criteria
- History of biological DMARDS.
- History/presence of acute heart disease, liver and kidney diseases, COPD
- Intolerance or allergy to fexofenadine or methotrexate
- Alcohol abuse
- Any changes in using medication (changing the dosage or type of medicines
- Receive hormone replacement therapy, warfarin, and other anticoagulants
Where it is running
2 locations listed.
- Beni-Suef Hospital - Banī Suwayf, Egypt
- Faculty of Medicine - Beni Suef Hospital - Banī Suwayf, Egypt