Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes
Recruiting · NCT05277025 · Observational (researchers observe without assigning treatment) · Lead sponsor: University of Florida
View the official record on ClinicalTrials.gov →What this trial is about
Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.
Who can take part
Age range
18 Years to 70 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Ages 18-70
- Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM
- Fulfills the 2010 ACR-EULAR classification criteria for RA
- Healthy volunteers: No significant pain/fatigue/depression/anxiety.
Exclusion criteria
- Diabetes
- Cancer
- Advanced liver, kidney or cardiovascular disease
- Neuropathic pain
Where it is running
2 locations listed across 1 US state.
- University of Florida - Gainesville, Florida, United States
- University of Florida - Gainesville, Florida, United States