Stand UP to Rheumatoid Arthritis (SUPRA)
Recruiting · NCT05305066 · Interventional (participants receive a specific treatment) · Lead sponsor: Marie Hudson, MD
View the official record on ClinicalTrials.gov →Interventions studied
Anti-IL6JAKiTNFi
What this trial is about
Rheumatoid arthritis is a disabling arthritis that affects young women disproportionately. Although the physicians have some excellent treatments, they do not know which treatment is best for which patient. The investigators want to find ways to identify the right drug for the right patient at the right time. This is what personalized medicine is all about.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age ≥ 18 years;
- Arthritis that fulfills the 2010 ACR/EULAR classification criteria for RA;
- Failure to standard conventional synthetic DMARDs and eligible for second-line b/tsDMARDs (Sub-study 1) or failure to at least one TNF inhibitor and eligible for third-line b/tsDMARDs (Sub-study 2).
Exclusion criteria
- Prior b/tsDMARDs for Sub-study 1 or prior b/tsDMARDs other than TNF inhibitors for Sub-study 2;
- Contraindication to b/tsDMARD therapy, such as active infection or untreated latent TB, current malignancy, severe organ dysfunction, history of VTE (unless anticoagulated), high risk of cardiovascular disease, pregnancy/lactation;
- Overlap with another inflammatory disease requiring specific immunosuppressive therapy, such as lupus nephritis;
- Unable to provide consent or complete forms (alone or with assistance) in English or French
Where it is running
1 location listed.
- Sir Mortimer B. Davis Jewish General Hospital - Montreal, Quebec, Canada