Fingolimod for Type 2 Diabetes Mellitus
Recruiting · NCT05307731 · Interventional (participants receive a specific treatment) · Lead sponsor: General Hospital of Shenyang Military Region
View the official record on ClinicalTrials.gov →Interventions studied
Fingolimodguideline-based treatment for DM
What this trial is about
The aim of this study is to explore the efficacy and safety of Fingoland in the treatment of type 2 diabetes. A total of 40 patients were randomly divided into two groups. One group was treated with fingolimod, another group was given guideline based treatment. The changes of islet function in patients with glycosylated hemoglobin, insulin and C-peptide were observed .
Who can take part
Age range
18 Years to 70 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 4
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age: 18-70 years old;
- clinically diagnosed type 2 diabetes.
- Glycosylated hemoglobin: 6.5% - 9.5%;
- No drug treatment or only one oral hypoglycemic drug within 6 months;
- Fasting blood glucose: \< 13.9mmol/l for those without medication, or \< 13.3mmol/l for those with medication;
- if the antidiabetic drugs are taken, the dosage and the drug must be stable in the past 3 months.
- Body mass index (BMI) ≤ 45 kg / m2;
- Sign informed consent
Exclusion criteria
- patients with type 1 diabetes;
- diabetic complications (ketoacidosis, hypertonic state, lactic acidosis).
- Allergic to the study drug;
- Abnormal liver and kidney function (transaminase greater than 2.5 times the upper limit of normal value; creatinine greater than 133umol / L);
- Complicated with other serious organ diseases;
- Recent disease history (within the past 6 months): myocardial infarction, unstable angina pectoris, stroke, transient ischemic attack, decompensated heart failure requiring hospitalization, or class III / IV heart failure;
- Presence or history of mobitz type II second or third degree AV block or sick sinus syndrome, unless the patient has a pacemaker;
- Baseline QT interval extension (male \> 450ms or female \> 460ms);
- Treatment with class IA or class III antiarrhythmic drugs;
- Patients with systemic infection (including but not limited to bacteria, fungi, viruses, etc.);
- Participating in other clinical trials within 3 months;
- Other circumstances that the investigator considers unsuitable for participating in this clinical study.
Where it is running
1 location listed.
- Department of Neurology, General Hospital of Northern Theater Command - Shenyang, China