Cytokine Expression in Psoriasis Patients With and Without Joint Involvement
Recruiting · NCT05307809 · Interventional (participants receive a specific treatment) · Lead sponsor: Poitiers University Hospital
View the official record on ClinicalTrials.gov →Interventions studied
Blood sample collectionSkin sample collection
What this trial is about
The objective of the resarch is to study the cytokine profile of patients with psoriatic arthritis and psoriasis in order to better understand the pathophysiology of the disease and the contribution of cytokines to the presence or absence of joint involvement. This research will compare cytokines levels in sera, in PBMC culture after LPS or CD3/CD28 agonist antibodies, and in skin biopsy.
Who can take part
Age range
18 Years to 100 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- For psoriasis patients :
- Age over 18 years old
- Signed informed consent
- 5 year old psoriasis at least
- At least one skin lesion over 2 cm
- Without any articular symptoms
- Without any DMARDs
- Without anticoagulant treatments or coagulation disease
- With normal articular and enthesis sonography
- For psoriatic arthritis patients :
- Age over 18 years old
- Signed informed consent
- Psoriatic arthritis according to CASPAR criteria
- Without any DMARDs
- Without anticoagulant treatments or coagulation disease
- With at least one synovitis at inclusion
- For controls
- Age and sex matched with a patient without any rheumatic or dermatologic medical conditions
- No treatment with corticosteroïds or non-steroïdial anti-inflammatory drugsAge over 18 years old
Exclusion criteria
- ▪ For psoriasis patients :
- Joint damage according to CASPAR criteria
- Echography activity in favor of chronic inflammatory rheumatism
- For patients and controls:
- Without social protection rights
- People under judiciary protection, of less than 18 years old, pregnant woman, breast feeding women, jailed patients.
Where it is running
1 location listed.
- Chu Poitiers - Poitiers, France