Labetalol or Nifedipine for Control of Postpartum Hypertension: A Randomized Controlled Trial
Recruiting · NCT05309460 · Interventional (participants receive a specific treatment) · Lead sponsor: Nebraska Methodist Health System
View the official record on ClinicalTrials.gov →Interventions studied
Labetalol Oral TabletNIFEdipine ER
What this trial is about
Randomized trial comparing risk of hospital readmission and hypertensive complications between patients managed on Labetalol compared to Nifedipine.
Who can take part
Age range
19 Years and older
Sex
Female
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 4
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Any patient admitted for delivery by cesarean or vaginal delivery at 24 weeks gestation or greater with hypertension(HTN). Hypertension will be defined during the study as either a systolic blood pressure ≥140mmHg or diastolic blood pressure ≥90mmHg on two occasions at least 4 hours apart. This definition is consistent with the ACOG definition for pregnancy related HTN. Following enrollment, treatment will be escalated at discretion of primary provider with the goal of normotension.
Exclusion criteria
- History of moderate persistent asthma, coronary artery disease, heart failure, AV heart block, pulmonary edema
- Contraindication to either Nifedipine or Labetalol
- HR \<60 or \>110
- Native language other than English or Spanish
Where it is running
1 location listed across 1 US state.
- Nebraska Methodist Women's Hospital - Omaha, Nebraska, United States