Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment
Recruiting · NCT05326399 · Observational (researchers observe without assigning treatment) · Lead sponsor: RenJi Hospital
View the official record on ClinicalTrials.gov →Interventions studied
renal biospy
What this trial is about
Investigators will conduct this single-center, prospective cohort study to explore the prevalence and risk factors of renal function progression in post-liver transplantation patients with renal impairment after renal biospy and to understand the the pathology of kidney disease in post-liver transplantation patients with renal impairment.
Who can take part
Age range
18 Years to 75 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- age 18-75 years
- patients received liver transplantation
- new onset of proteinuria(defined as 24-hour proteinuria\>1g/24h, or Urinary albumin creatinine ratio(UACR)\>300mg/g on at least two occasions), and/or renal impairment: eGFR \<60 mL/min/1.73 m² at least two occasions, and/or serum creatinine increase ≥50% from baseline
- have received renal biopsy in the past 3 months
- Signed informed consent form(ICF)
Exclusion criteria
- patients received renal transplantation
- hepatic failure
- severe bleeding risk or platelet \<70\*109/L
- chronic kidney insufficiency with eGFR\<30ml/min·1.73m2,or kidney atrophy, or solitary kidney, or medullary sponge kidney, or polycystic kidney, or obstructive nephropathy
- uncontrolled mental disease or unable to cooperate during operation
- Pregnancy or lactation
- not suitable for this study judged by investigaters
Where it is running
2 locations listed.
- Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine - Shanghai, China
- Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine - Shanghai, China