The Effect of Beta-blocker on Chronotropic Response and Cardiorespiratory Fitness in Patients With Atrial Fibrillation
Recruiting · NCT05332457 · Interventional (participants receive a specific treatment) · Lead sponsor: National Taiwan University Hospital
View the official record on ClinicalTrials.gov →Interventions studied
Reduced dosage of beta-blocker
What this trial is about
This is a prospective study to evaluate changes in exercise capacity and chronotropic response to exercise before and after beta-blocker dosage reduction in patients with atrial fibrillation (AF).
Who can take part
Age range
20 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- \> 20 years of age.
- Clinically stable patients with persistent atrial fibrillation using beta-blocker as rate-control agent without dosage adjustment for at least 3 months.
- Resting heart rate \< 80 bpm.
- Left ventricular ejection fraction \> 50%.
Exclusion criteria
- Beta-blocker usage due to indications other than rate control for atrial fibrillation.
- Inability to perform a cardiopulmonary exercise testing.
- Presence of contraindications for cardiopulmonary exercise testing according to the American College of Sports Medicine's Guidelines for Exercise Testing and Prescription.
- Patients with implantable cardioverter defibrillator or pacemaker.
- Pregnancy.
- Inability to provide informed consent.
Where it is running
1 location listed.
- National Taiwan University Hospital - Taipei, Taiwan