Renal Nerve Stimulation in Uncontrolled Hypertensive Patients Undergoing Renal Denervation
Recruiting · NCT05421767 · Interventional (participants receive a specific treatment) · Lead sponsor: National Taiwan University Hospital
View the official record on ClinicalTrials.gov →Interventions studied
nerve stimulation guided renal denervation procedure
What this trial is about
Study design: Investigator initiated, single center The study is aimed 1\) To investigate the blood pressure (BP) change to renal nerve stimulation(RNS), and subsequently perform a renal denervation(RDN) procedure 1\) to verify the cutoff value (RNS-induced systolic BP change \<20 mmHg in post-RDN patients) could be a useful clinical endpoint in RDN therapy, and test the hypothesis that intense RDN could improve the efficacy of RDN.
Who can take part
Age range
20 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 4
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Patients with hypertension (HTN), including
- 24-hour ambulatory blood pressure \>130/ 80 mmHg
- Age 20-80 years
- Glomerular filtration rate \>45 mL/min
Exclusion criteria
- Unsuitable renal artery anatomy computed tomographic angiography (main renal artery lumen diameter ≤3 mm or a total length \<20 mm of the main arteries).
- untreated secondary HTN, including hyperaldosteronism, pheochromocytoma, renal artery stenosis(\>50% stenosis)
Where it is running
1 location listed.
- National Taiwan University Hospital - Taipei, Taiwan