Early Pulmonary Dysfunction in Childhood Cancer Patients
Recruiting · NCT05427136 · Observational (researchers observe without assigning treatment)
View the official record on ClinicalTrials.gov →Interventions studied
Breath AnalysisCollection of genetic samplesData collection for assessment of clinical parameters and cumulative doses to chemotherapy, radiation, surgery and HSCTLung function measurementsMagnetic resonance imaging (MRI)Standardized interview to assess respiratory symptoms
What this trial is about
This longitudinal, prospective, multicentre study is to monitor lung function prospectively in childhood cancer patients after diagnosis. The impact of cancer treatment on pulmonary dysfunction non-invasively using lung function, lung imaging and breath analysis as well as clinical symptoms using a questionnaire will be assessed at different time points.
Who can take part
Age range
4 Years to 22 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- at least one of the following cancer treatments:
- chest radiation
- treatment with any kind of chemotherapy
- hematopoietic stem cell transplantation (HSCT)
- thoracic surgery
- consent for Childhood Cancer Registry (ChCR) registration
Exclusion criteria
- no signed informed consent
- Operation outside the chest area as only cancer treatment
- Relapsed cancer (patients who develop relapse during the study will not be excluded)
- In addition for MRI and lung function tests:
- Subjects who are respiratory insufficient and cannot perform a lung function test (less than 92% O2 saturation; under O2 therapy)
- Pregnant
- MRI measurement not possible without sedation
- Metal (e.g. pacemaker) in the body
Where it is running
5 locations listed.
- University Children's Hospital Basel (UKBB) - Basel, Switzerland
- Universitätsklinik für Kinderheilkunde - Bern, Switzerland
- Geneva University Hospital - Geneva, Switzerland
- Centre hospitalier universitaire vaudois Lausanne - Lausanne, Switzerland
- Universitäts-Kinderspital Zürich - Zurich, Switzerland