Nodule IMmunophenotyping Biomarker for Lung Cancer Early Diagnosis Study
Recruiting · NCT05432739 · Observational (researchers observe without assigning treatment) · Lead sponsor: Royal Marsden NHS Foundation Trust
View the official record on ClinicalTrials.gov →What this trial is about
NIMBLE is a prospective study for blood biomarker study of lung nodules alongside analysing data which has been collected routinely as part of patient care. The primary aim of NIMBLE is to assess whether artificial intelligence and machine learning based radiomics approaches can be used to distinguish between benign disease and malignancy in a new lung nodule after a previously treated cancer, and where malignant to differentiate between metastatic recurrence or a new primary lung cancer.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Patients under active investigation or surveillance for incidental lung nodules
- Age \> 18.
Exclusion criteria
- Active or previous diagnosis of malignancy (within 5 years preceding baseline scan).
- Inability to give informed consent.
- Active infection (including tuberculosis or fungal infection).
- Clinician-suspected or confirmed active or recent COVID-19 infection (less than 4 weeks before CT scan or required blood sampling date).
Where it is running
9 locations listed.
- Calderdale and Huddersfield NHS Foundation Trust - Huddersfield, United Kingdom
- Princess Alexandra Hospital - London, United Kingdom
- Whittington Health NHS Trust - London, United Kingdom
- University College London Hospitals NHS Foundation Trust - London, United Kingdom
- Guy's and St Thomas' NHS Foundation Trust - London, United Kingdom
- Royal Marsden Hospital - London, United Kingdom
- Northumbria NHS Foundation Trust - Newcastle upon Tyne, United Kingdom
- Nottinghamshire Healthcare NHS Foundation Trust - Nottingham, United Kingdom
- Barking Havering and Redbridge University Hospitals NHS Trust - Goodmayes, Essex, United Kingdom