UK Heart Failure With Preserved Ejection Fraction
Recruiting · NCT05441839 · Observational (researchers observe without assigning treatment) · Lead sponsor: Manchester University NHS Foundation Trust
View the official record on ClinicalTrials.gov →What this trial is about
Heart failure occurs when the heart is no longer able to pump blood around the body properly. It can cause breathlessness, swollen feet and ankles, and tiredness. In about half of patients with heart failure, one measure of the heart's pumping function, called the 'ejection fraction', is normal. This type of heart failure is called heart failure with preserved ejection fraction, or HFpEF. HFpEF remains poorly understood. It is not clear why some people develop HFpEF, or what determines the severity of the condition. Treatment options may be limited. UK HFpEF is a study that aims to gain a better understanding of why people develop HFpEF, develop better tests to diagnosis it, identify and test new treatments, and follow the health of the people taking part over many years.
Who can take part
Inclusion criteria
- Written informed consent
- Diagnosis of HFpEF by a cardiologist with HF expertise, or a primary care physician with HF expertise, or a heart failure nurse
- Natriuretic peptide levels measured
Exclusion criteria
- LV EF \< 40% (at screening or any previous measurement)
- Known infiltrative cardiomyopathy (e.g., amyloid, sarcoid, lymphoma, endomyocardial fibrosis)
- Known active myocarditis, constrictive pericarditis, or cardiac tamponade
- Known genetic hypertrophic cardiomyopathy or obstructive hypertrophic cardiomyopathy
- Known arrhythmogenic right ventricular cardiomyopathy
- Known severe primary valvular heart disease
- Known idiopathic, heritable or drug-induced pulmonary arterial hypertension
- Heart transplantation or ventricular assist device
- Complex congenital heart disease
Where it is running
26 locations listed.
- Cwm Taf Morgannwg University Health Board - Abercynon, United Kingdom
- Buckinghamshire Healthcare NHS Trust - Aylesbury, United Kingdom
- University Hospitals Birmingham NHS Foundation Trust - Birmingham, United Kingdom
- Broomfield Hospital - Chelmsford, United Kingdom
- NHS Tayside - Dundee, United Kingdom
- Glasgow Royal Infirmary - Glasgow, United Kingdom
- West Suffolk NHS Foundation Trust - Ipswich, United Kingdom
- Kettering General Hospital - Kettering, United Kingdom
- Leeds Teaching Hospitals NHS Trust - Leeds, United Kingdom
- University Hospitals of Leicester NHS Foundation Trust - Leicester, United Kingdom
- Barnet Hospital - London, United Kingdom
- Guys and St. Thomas' NHS Foundation Trust - London, United Kingdom
- Imperial College Healthcare NHS Trust - London, United Kingdom
- Manchester University NHS Foundation trust - Manchester, United Kingdom
- The James Cook University Hospital - Middlesbrough, United Kingdom
- Northumbria Healthcare NHS Foundation Trust - Newcastle upon Tyne, United Kingdom
- Norfolk & Norwich University Hospitals NHS Foundation Trust - Norwich, United Kingdom
- George Eliot Hospital - Nuneaton, United Kingdom
- North West Anglia NHS Foundation Trust - Peterborough, United Kingdom
- University Hospitals Dorset NHS Foundation Trust - Poole, United Kingdom
- Betsi Cadwaldr University Health Board - Rhyl, United Kingdom
- Salisbury NHS Foundation Trust - Salisbury, United Kingdom
- Sheffield Teaching Hospitals NHS Foundation Trust - Sheffield, United Kingdom
- University Hospital of North Tees - Stockton-on-Tees, United Kingdom
- South Tyneside & Sunderland NHS Foundation Trust - Sunderland, United Kingdom
- Southend University Hospital - Westcliff-on-Sea, United Kingdom