Deep Brain Stimulation for Refractory Trigeminal Neuralgia with a Pontine Lesion
Recruiting · NCT05451251 · Interventional (participants receive a specific treatment) · Lead sponsor: Université de Sherbrooke
View the official record on ClinicalTrials.gov →Interventions studied
Deep brain stimulation
What this trial is about
The aim of this study is to assess the feasibility of deep brain stimulation for refractory trigeminal neuralgia due to a pontine lesion, as is usually seen in the context of multiple sclerosis. These patients usually have severe intractable facial pain and current medical and surgical options generally fail to achieve long lasting pain relief. Hoping to improve pain control in this population, the investigators of this trial propose a novel technique consisting of implanting a deep brain stimulation lead within the pontine lesion to modulate the generation of pain signals.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 1
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Adults of at least 18 years old
- Refractory trigeminal neuralgia : failure of at least 3 drugs and at least two lesioning surgical interventions (radiosurgery, percutaneous rhizotomy, or open rhizotomy).
- Pontine lesion proved by MRI in contact with trigeminal nerve tract
Exclusion criteria
- Absolute contraindication to MRI
- Medical contraindication to the procedure
Where it is running
1 location listed.
- Centre Hospitalier Universitaire de Sherbrooke (CHUS) - Sherbrooke, Quebec, Canada