The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma
Recruiting · NCT05496582 · Observational (researchers observe without assigning treatment) · Lead sponsor: Shanghai University of Traditional Chinese Medicine
View the official record on ClinicalTrials.gov →Interventions studied
No intervention
What this trial is about
Asthma is one of the most common chronic respiratory diseases. Previous study found a series of differentially expressed genes and proteins (transgelin-2, metallothionein-2, ezrin) in asthmatic rat. The aim of the study is to investigate the changes and associations of these gene with asthma in human.
Who can take part
Age range
14 Years to 75 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Males or females, aged 14-75 years;
- Patients with a definite diagnosis of bronchial asthma;
- The diagnosis of asthma according to the Global Initiative for Asthma (GINA), with positive bronchodilator responsiveness (reversibility) test;
- Healthy volunteers without respiratory symptoms such as cough, wheezing, chest tightness or dyspnea;
- Agree with all procedures in this trial by signing a written informed consent form.
Exclusion criteria
- Patients with chronic obstructive pulmonary disease or other airway disease;
- Complicated with other severe primary diseases (including hypertension, cancer, hyperthyroidism, bronchiectasia, cardiac insufficiency) and conditions that would prevent participation in the trial or put the participant at risk;
- Women who are known to be pregnant or breastfeeding;
- Not willing to participate;
- Psychiatric history and neurological disorders can not work normally;
- Other conditions that the researcher considers inappropriate to participate in this study.
Where it is running
2 locations listed.
- Xiangya Hospital, Central South University - Changsha, Hunan, China
- Yueyang Hospital, Shanghai University of Traditional Chinese Medicine - Shanghai, Shanghai Municipality, China