A Real World Study of Ensartinib in Advanced ALK-positive NSCLC
Recruiting · NCT05498064 · Observational (researchers observe without assigning treatment)
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The primary objective of this study is to evaluate the efficacy and safety of Ensartinib in advanced ALK-positive non-small cell lung cancer, and the mechanisms of population pharmacokinetics and resistance to Ensartinib.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Histologically or cytologically confirmed stage III b or IV NSCLC, according to the International Association for the Study of Lung Cancer staging manual in Thoracic Oncology, 8th edition.
- Documented ALK-positive disease according to FISH , Ventana IHC ,RT-PCR or NGS;
- Patients must have demonstrated progression during or after ALK-TKI treatment;
- Eastern cooperative oncology group performance status (ECOG PS) of 0-2, overall survival\>3 months;
- Patients need radiotherapy or can receive radiotherapy, such as bone metastatic lesions, intrapulmonary lesions, adrenal lesions, etc.
- Initially general blood tests including complete blood count, biochemistry, electrolytes, and urine biochemistry were performed as a routine screening in order to identify any abnormalities.
- Male and female patients must agree to abstain or to use two highly effective forms of contraception during the treatment period and for 90 days after the last dose of study medication.
Where it is running
1 location listed.
- Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital - Beijing, Beijing Municipality, China