Targeting LOXL2 and Cardiac Fibrosis for Post-acute Heart Failure Treatment- A Prospective Study
Recruiting · NCT05498584 · Observational (researchers observe without assigning treatment) · Lead sponsor: Chang Gung Memorial Hospital
View the official record on ClinicalTrials.gov →Interventions studied
exercise based cardiac rehabilitation
What this trial is about
A previous study demonstrated that a multidisciplinary cardiac rehabilitation (CR) program was associated with reduced medium- to long-term all-cause mortality in a retrospective propensity score-matched study. The investigators will further investigate the predictors including LOXl2, cardiac MRI, and endothelial function that will benefit from a successful CR.
Who can take part
Age range
20 Years to 100 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Patients must give written informed consent before any assessment is performed.
- Inpatients \>= 20 years of age, male or female.
- Patients with a diagnosis of heart failure New York Heart Association (NYHA) class II-IV with BNP \>=100 pg/mL or NT-porBNP \>= 400 pg/mL ( \>= 900 pg/mL if concomitant atrial fibrillation)
- Left ventricular ejection fraction \<= 40% by echocardiography or other methods
Exclusion criteria
- Estimated survival time \< 6 months
- Long-term bedridden for more than 3 months
- Cannot tolerate exercise test due to muscular skeletal disorder.
- Cannot cooperate all functional studies
- Ventilator dependent
- Terminal heart status
- Family rejects to participate in this project
- Primary severe valvular heart disease
Where it is running
1 location listed.
- Chang Gung Memorial Hospital Heart Failure Center - Kaohsiung City, Taiwan