Post-ablation Alcohol Impacts Arrhythmia Recurrence, Quality of Life and Cognition in AF
Recruiting · NCT05510167 · Interventional (participants receive a specific treatment)
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Earlier studies have shown a dose-dependent relationship between alcohol intake and incident atrial fibrillation (AF) as well as a causal link with several risk factors for AF such as hypertension, obesity and sleep apnea. However, the effect of drinking (alcohol) on post-ablation outcome such as arrhythmia recurrence, quality of life (QoL) and cognitive function in AF patients is unclear. Therefore, we aim to find the answer for a very frequently asked question, "is it safe to continue drinking alcohol (at the pre-ablation level) following catheter ablation OR should the intake be reduced for better outcome?", in this randomized trial.
Who can take part
Inclusion criteria
- AF patients that regularly consume \>5 alcoholic drink (\*12 g of pure alcohol/drink)/week
- Paroxysmal or persistent AF
- First catheter ablation History of alcohol-induced arrhythmia
- Willing to sign the written informed consent
Exclusion criteria
- Binge drinkers (alcohol dependence)
- Non-drinkers
- LVEF \<35%
- Psychiatric conditions
- MoCA score ≤ 17 on Montreal Cognitive Assessment (MoCA)
- Patients with established dementia
- Medically unstable patients (acute/unstable or poorly controlled problems that would demand focused, relatively urgent or emergent medical attention)
- Unwilling for alcohol-abstinence
- Long-standing persistence AF
- Patient under legal protection
- Pregnancy
Where it is running
1 location listed across 1 US state.
- Texas Cardiac Arrhythmia Institute, St. David's Medical Center - Austin, Texas, United States