Safest Choice of Antihypertensive Regimen for Postpartum Hypertension
Recruiting · NCT05551104 · Interventional (participants receive a specific treatment) · Lead sponsor: Loma Linda University
View the official record on ClinicalTrials.gov →Interventions studied
Oral LabetalolOral Nifedipine
What this trial is about
The purpose of this investigator-initiated randomized control trial is to determine whether oral Nifedipine versus oral Labetalol is superior in controlling high blood pressures in the postpartum period.
Who can take part
Age range
18 Years and older
Sex
Female
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 3
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Female
- Women who develop postpartum hypertension\* after delivery of the placenta or chronic hypertensive postpartum women who require medication for blood pressure control.
- Postpartum hypertension requiring treatment are defined as systolic blood pressure greater than or equal to 140mmHg or diastolic blood pressure greater than or equal to 90mmHg on at least 2 occasions at least 4 hours apart, or systolic blood pressure greater than or equal to 160mmHg or diastolic blood pressure greater than 110mmHg sustained for more than 15 minutes.
Exclusion criteria
- History of moderate persistent asthma, coronary artery disease, heart failure, AV heart block, pulmonary edema
- Contraindication to either Nifedipine or Labetalol
- HR \<60 or \>110
- Native language other than English or Spanish
Where it is running
1 location listed across 1 US state.
- Loma Linda University Health - Loma Linda, California, United States