Therapeutic Mechanisms of Epidural Spinal Cord Stimulation
Recruiting · NCT05556902 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Alabama at Birmingham
View the official record on ClinicalTrials.gov →Interventions studied
Permanent Epidural Spinal Cord Stimulation
What this trial is about
The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS, and finally 3) whether different SCS waveforms elicits stimulus-evoked compound action potentials (ECAPs) in spinal cord and at the cortex (electroencephalography, and magnetoenchphalography).
Who can take part
Age range
18 Years to 89 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Male or Female, age 18-89
- Chronic pain for more than 3 months
- Willing to visit a research lab
- Willing to undergo a blood draw
- Able to provide written informed consent
Exclusion criteria
- History of neurological disease (e.g., dementias, Parkinson's)
- History of stroke
- Current diagnosis of cancer
- Subject is unwilling or unable to comply with the protocol
Where it is running
1 location listed across 1 US state.
- University of Alabama at Birmingham - Birmingham, Alabama, United States