Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease
Recruiting · NCT05557864 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Minnesota
View the official record on ClinicalTrials.gov →Interventions studied
Deep Brain Stimulation
What this trial is about
This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant to dopamine replacement therapy, these experiments will likely have major impact on clinical practice by providing a potential strategy to these medically intractable symptoms.
Who can take part
Age range
21 Years to 89 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- diagnosis of idiopathic PD
- have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN)
- Existing 7T brain imagery
Exclusion criteria
- history of musculoskeletal disorders that significantly affect movement of the upper or lower limbs
- other significant neurological disorder
- history of dementia or cognitive impairment as found with UBACC (or MacCAT-CR)
- post-operative complications or adverse effects
Where it is running
1 location listed across 1 US state.
- University Of Minnesota - Minneapolis, Minnesota, United States