NOAC9 - Circulating Tumor DNA Guided Follow-Up in Anal Cancer
Recruiting · NCT05572801 · Interventional (participants receive a specific treatment) · Lead sponsor: Aarhus University Hospital
View the official record on ClinicalTrials.gov →Interventions studied
AMR B: HPV positive ctDNA guided imaging in follow-up
What this trial is about
This study investigates if circulating tumor DNA can improve the detection of early treatment failure or recurrence in localized squamous cell carcinoma of the anus (SCCA) after curative chemoradiotherapy thereby increasing the potential for cure. This will be done by comparing the standard follow-up program with ctDNA guided imaging follow-up. Secondly, the aim is to establish early interventions against late morbidities.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Patients with SCCA eligible for definitive (chemo)radiotherapy
- ≥ 18 of years
- Written and oral consent
Exclusion criteria
- Conditions that will contraindicate blood samples
- Conditions that will contraindicate a PET-CT scan.
- Potential lack of compliance to standard FU program and study participation.
Where it is running
13 locations listed.
- Aarhus University Hospital - Aarhus, Denmark
- Haukeland University Hospital - Bergen, Norway
- Sahlgrenska University Hospital - Gothenburg, Sweden
- Skåne University Hospital Lund - Lund, Sweden
- Oslo University Hospital - Oslo, Norway
- Karonlinska University Hospital - Stockholm, Sweden
- Tampere University Hospital - Tampere, Finland
- University Hospital of North Norway - Tromsø, Norway
- St. Olav's University Hospital - Trondheim, Norway
- Turku University Hospital - Turku, Finland
- Norrlands University Hospital - Umeå, Sweden
- Department of Oncology Herlev and Gentofte Hospital - Herlev, Capital Region of Denmark, Denmark
- Department of Oncology, Vejle Hospital - Vejle, The Regions of Southern Denmark, Denmark