Shanghai At Risk for Alzheimer's Disease: a Cohort Study
Recruiting · NCT05597410 · Observational (researchers observe without assigning treatment) · Lead sponsor: Ruijin Hospital
View the official record on ClinicalTrials.gov →What this trial is about
The goal of this cohort study is to estimate the incidence of AD in the first-degree relatives of patients with AD. The main questions it aims to answer are: * cognitive changes of subjects at high risk of AD as ageing; * environmental and behavioral factors affecting AD incidence.
Who can take part
Age range
50 Years and older
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- the AD diagnostic criteria of probands meet the 2011 National Institute on Aging - Alzheimer's Association framework, and participants are the first-degree relatives (including parents, children and siblings of the same father and mother) of the proband;
- not patients with dementia;
- ≥ 50 years, males and females;
- subjects have lived in Shanghai for more than 1 year and have no plan to move out of Shanghai within 5 years;
- subjects are able to complete investigation, physical examination, imaging examination and biological specimen collection.
Exclusion criteria
- Individuals will be excluded if they have:
- other diseases which could cause cognitive decline, e.g. cerebrovascular diseases, Creutzfeldt-Jakob disease and Parkinsons disease;
- history of psychological disorders (according to Diagnostic and Statistical Manual of Mental Disorders, 5th Edition);
- uncorrectable visual or auditory impairment that hampers the completion of related examination.
- pre-menopausal women will also be excluded.
Where it is running
1 location listed.
- Ruijin Hospital, Shanghai Jiao Tong University School of Medicine - Shanghai, Shanghai Municipality, China