The Clinical Efficacy of Immunomodulators in RA Patients
Recruiting · NCT05626348 · Interventional (participants receive a specific treatment) · Lead sponsor: Qilu Hospital of Shandong University
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
This study includes naive patients and csDMARDs-IR RA patients, treated with different regimens such as Iguratimod combination of different csDMARDs, or csDMARD with TNF inhibitors for 24 weeks. The disease activity and drug response will be observed. The immune disorder and synovial function will be evaluated at the same time.
Who can take part
Age range
18 Years to 80 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 4
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Patients with RA who meet ACR 1987 rheumatoid arthritis classification criteria or ACR/EULAR 2010 rheumatoid arthritis Classification Criteria and have knee dysfunction.
- ACR 1987 rheumatoid arthritis classification criteria
- morning stiffness lasting at least 1 hour (≥6w)
- there are 3 or more joint areas swollen (≥6w)
- swelling of the wrist, metacarpophalangeal, and proximal phalangeal joint areas (≥6w)
- symmetrical arthrogryposis (≥6w)
- hand x-ray changes (at least osteoporosis and joint space narrowing)
- positive rheumatoid factor (titer \> 1:32) RA can be diagnosed by meeting 4 of the above 7 items
- ACR/EULAR 2010 rheumatoid arthritis Classification Criteria
- Involved joints
- \- 1 large joint (0 points)
- 2-10 large joints (1 point)
- 1-3 small joints (with or without large joints) (2 points)
- 4-10 small joints (with or without large joints) (3 points)
- more than 10 small joints (at least one small joint) (5 points)
- Serological indicators
- RF and ACPA negative (0 points)
- RF and ACPA, at least one of which is low titer positive. (2 points)
- RF and ACPA with at least one high titer positive (3 points)
- Acute chronotropic reactants
- Both CRP and ESR normal (0 points)
- Abnormal CRP or ESR (1 point)
- Duration of synovitis
- \<6 weeks (0 points)
- ≥6 weeks (1 point)
- Patients with OA who meet the 1995 Classification Criteria for OA and have knee dysfunction 1995 Classification Criteria for Osteoarthritis of the Knee Clinical criteria
- a. Knee pain most of the time in the last 1 month b. Bone rubbing sound c, morning stiffness ≤ 30 minutes d, age ≥ 38 years e, with bony enlargement Knee OA can be diagnosed if a+b+c+d or a+b+e is met
- Age-sex matched healthy volunteers who checked in our hospital.
- Age \> 18 years old;
- Voluntarily participate in this study and sign an informed consent form
Exclusion criteria
- Patients with combined active hepatitis
- Patients with active tuberculosis
- Patients withinfection and malignancy
Where it is running
1 location listed.
- Qilu Hospital - Jinan, Shandong, China