Analysis of the Microenvironment of Lung Cancer and Exploration of the Mechanism of Resistance to Immunotherapy
Recruiting · NCT05636605 · Observational (researchers observe without assigning treatment) · Lead sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine
View the official record on ClinicalTrials.gov →Interventions studied
Multiomics analysis
What this trial is about
The investigators plan to conduct a multiomics analysis（such as, Genomics, proteomics, single cell RNA sequencing, space transcriptomics）of tumor tissue and blood, aiming at analyzing tumor heterogeneity, mapping the microenvironment map of lung cancer and exploring the mechanism of sensitivity and resistance to anti-PD1/PD-L1 antibodies.
Who can take part
Age range
18 Years to 80 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Histopathology or hemology diagnostics of lung cancer
- Patients have never received any antineoplastic therapy
Exclusion criteria
- Within 5 years or at the same time, there are other active malignancies
- Currently participating in interventional clinical research treatment, or received other research drugs or used research devices within 4 weeks before the first administration
- Active autoimmune diseases requiring systemic treatment (such as the use of disease relieving drugs, glucocorticoids or immunosuppressants) occurred within 2 years before the first administration
- The study was receiving systemic glucocorticoid treatment (excluding local glucocorticoids by nasal spray, inhalation or other means) or any other form of immunosuppressive therapy within 7 days before the first administration; Note: It is allowed to use glucocorticoid with physiological dose (prednisone ≤ 10mg/day or equivalent)
- Known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation
Where it is running
1 location listed.
- The Fourth Affiliated Hospital of Zhejiang University - Yiwu, Zhejiang, China