Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis
Recruiting · NCT05642156 · Interventional (participants receive a specific treatment) · Lead sponsor: Medical University of Graz
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Patients treated with hemodialysis (HD) bear increased risk of cardiovascular events, which results in high morbidity and mortality among this cohort of patients. Intradialytic hypotension (IDH), which is an independent risk factor for mortality, occurs in up to 20% of hemodialysis session and may lead to myocardial stunning and cerebral ischemia resulting in increased white matter lesions, gastrointestinal ischemia and shunt vessel thrombosis. Due to the deleterious effects of IDH during HD, preventive measurements such as limiting interdialytic weight gain are recommended, but frequently fluid and salt restriction are not adhered to, thus increasing dialysis time or frequency of treatments is a common strategy in those patients.
Who can take part
Inclusion criteria
- Written consent of the participant after being informed
- At least 18 years of age
- End stage kidney disease patient undergoing hemodialysis
- Dry weight stable for a minimum of one month
- Interdialytic weight gain of \>2 liters in the short interdialytic interval
Exclusion criteria
- No informed consent was obtained
- Patients with a pacemaker or implanted medical device that prevents compliance with study regulations
- Patients treated with hemodiafiltration
- Patients treated with medium cut-off membranes (Theranova, Baxter)
- Patients with recurrent severe hyperkalemia after the short interdialytic interval (K+ concentration \> 6.0 mmol/L, requiring more than 2 hours of dialysis to ameliorate the post-dialytic shift from other compartments.
- Women of childbearing age not using contraception
Where it is running
1 location listed.
- Medical University of Graz - Graz, Austria