Imaging the Pathogenesis of Cerebral Small Vessel Disease
Recruiting · NCT05703386 · Observational (researchers observe without assigning treatment) · Lead sponsor: Johns Hopkins University
View the official record on ClinicalTrials.gov →What this trial is about
Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Clinical or radiographic evidence of ischemic stroke
- One vascular risk factor (hypertension, hyperlipidemia, or diabetes)
- Evidence of cerebral small vessel disease on MRI
Exclusion criteria
- Inability to complete 3 research MRI scans over 1.25 years
Where it is running
1 location listed across 1 US state.
- Kennedy Krieger Institute - Baltimore, Maryland, United States