Fluid Challenge and Plasma Volume, During Surgery
Recruiting · NCT05726136 · Interventional (participants receive a specific treatment) · Lead sponsor: Joachim Zdolsek
View the official record on ClinicalTrials.gov →Interventions studied
acetated Ringersalbumin 20%albumin 5%
What this trial is about
A short bolus infusion of fluid, called "fluid challenge" is commonly recommended for fluid treatment during longer surgery. However a prolonged increase of the blood volume is a prerequisite to recommend the technique. The purpose with the study is to examine the plasma expanding effect of three different fluid challenge strategies (acetated Ringers 4 ml/kg body weight, albumin 5% 4 ml/kg body weight or albumin 20% 1 ml/kg body weight), using hemoglobin as a dilution indicator.
Who can take part
Age range
18 Years to 85 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 4
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Written consent to participate in the study
- For women: relevant contraceptive, menopausal or a negative pregnancy test.
- ASA category I to III
- Laparoscopic abdominal surgery, with a duration of at least 90 minutes.
- 18 to 85 years
Exclusion criteria
- Patients with known cardiac failure
- \<18 or \>85 years
- known allergy to albumin
- extracellular hyperhydration or hypervolemia
- kidney failure
- pregnancy or planned pregnancy
Where it is running
1 location listed.
- Vrinnevi Hospital - Norrköping, Östergötland County, Sweden