At High-risk for Pre-eclampsia After Assisted Reproductive Technology

Inclusion criteria

• First time oocyte acceptors Or Nulliparous PCOS patients undergoing ART (IVF/ICSI)
• Criteria for PCOS: two out of the three following criteria must be present:
• Oligo-or anovulation: a menstrual cycle \>35 days
• Hyperandrogenism:
• Clinically: the presence of hirsutism and/ or severe acne in combination with alopecia confirmed hyperandrogenism Or
• Biochemically: serum total testosterone \>52 ng/dl or calculated free testosterone \>0,64 ng/dl
• Polycystic ovaries:
• Follicle number per ovary (FNPO) ≥ 12 on both ovaries Or
• Ovarian volume ≥ 10 ml in both ovaries Or
• One ovary with ≥ 20 follicles (Using endovaginal US transducers with a frequency bandwidth that includes 8 MHz) Or
• AMH ≥ 4,9 ng/ml

Exclusion criteria

• Known essential hypertension or development of a new-onset hypertension before 20 weeks' gestation
• Hypertension is defined as a systolic blood pressure ≥ 140 or a diastolic blood pressure ≥ 90 on two separate measurements with at least 20 minutes in between, taken when the patients is in a seated position Or
• The patient is known with hypertension, diagnosed by a certified doctor
• Known diabetes type 1 or 2 before pregnancy
• Diagnosis of diabetes is confirmed when one of the following is present:
• Fasting glucose ≥ 126 mg/dl
• A 2-hour plasma glucose level ≥ 200 mg/dL during a 75-g oral glucose tolerance test Or
• The patient is known with diabetes (type 1 or 2), diagnosed by a certified doctor
• Thyroid dysfunction not under control with medication:
• Hyperthyroidism, the diagnoses is made when:
• Peripheral blood TSH \<0,5 mIU/L and fT4 \>1,9 ng/dl Or
• When the patient is known with hyperthyroidism diagnosed by a certified physician
• Hypothyroidism, the diagnosis is made when:
• Peripheral blood TSH \>5 mIU/L and fT4 \<0,7 ng/dl Or
• When the patient is known with hypothyroidism diagnosed by a certified physician
• Other endocrinological disorder (including Cushing syndrome, Adrenal insufficiency, acromegaly): for diagnosis we will trust the opinion of the certified endocrinologist
• Cardiovascular diseases (including coronary artery disease, arrhythmia, heart valve disease and heart failure): for diagnosis we will trust the opinion of the certified cardiologist
• Renal disease/insufficiency: for diagnosis we will trust the opinion of the certified nephrologist
• Systemic lupus erythematosus: for diagnosis we will trust the opinion of the certified internal medicine doctor
• Antiphospholipid syndrome: for diagnosis we will trust the opinion of the certified internal medicine doctor
• Liver dysfunction/disease: for diagnosis we will trust the opinion of the certified gastroenterologist
• History of prior pre-eclampsia
• Women pregnant with a fetus with known abnormalities such chromosomal anomalies, structural deformities of limbs or organs or any other prebirth diagnosed syndromes or defects
• Multiple pregnancy