A Study on the Effects of Exercise Therapy on Signs of Prostate Cancer
Recruiting · NCT05751434 · Interventional (participants receive a specific treatment) · Lead sponsor: City of Hope Medical Center
View the official record on ClinicalTrials.gov →Interventions studied
Exercise Therapy
What this trial is about
To determine the effects of exercise therapy on molecular, radiologic, and pathologic nimbosus hallmarks versus usual care control in men on Active Surveillance for localized prostate cancer.
Who can take part
Age range
18 Years and older
Sex
Male
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 2
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age ≥ 18
- Men with histologically confirmed localized prostate cancer undergoing active surveillance.
- Inactive, defined as not meeting the national exercise guidelines for cancer patients (\<150 minutes/week of moderate or vigorous exercise)43 as assessed by remote activity and heart rate tracking for a 7-day period prior to study entry (general physical activity screening assessment via smart watch).
- Screening clearance by an MSK Exercise Physiologist (i.e., review of ECG)
- BMI \<40 kg/m\^2
- Cleared for exercise participation as per pre-screening clearance via the Physical Activity Readiness Questionnaire (PAR-Q+) (Appendix B)
Exclusion criteria
- Enrollment in any other program that may alter the impact of exercise on tumor outcomes (e.g., weight loss program)
- Any neoadjuvant anticancer treatment of any kind for prostate cancer in the last 5 years
- Any history of systemic anticancer therapy in the last 15 years
- Distant metastatic malignancy of any kind
- Any other condition or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation
Where it is running
10 locations listed across 4 US states.
- City of Hope Medical Center - Durate, California, United States
- University of California, Los Angeles (Data and Specimen Analysis Only) - Los Angeles, California, United States
- Hartford Healthcare Alliance (Data collection only) - Hartford, Connecticut, United States
- Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) - Basking Ridge, New Jersey, United States
- Memorial Sloan Kettering Monmouth (Limited protocol activities) - Middletown, New Jersey, United States
- Memorial Sloan Kettering Bergen (Limited protocol activities) - Montvale, New Jersey, United States
- Memorial Sloan Kettering Suffolk - Commack (Limited protocol activities) - Commack, New York, United States
- Memorial Sloan Kettering Westchester (Limited protocol activities) - Harrison, New York, United States
- Memorial Sloan Kettering Cancer Center (All Protocol Activities) - New York, New York, United States
- Memorial Sloan Kettering Nassau (Limited protocol activites) - Rockville Centre, New York, United States