SPEECH as Biomarker for Emotion, Movement and cOgnition in Parkinson's Disease
Recruiting · NCT05765110 · Interventional (participants receive a specific treatment) · Lead sponsor: Insel Gruppe AG, University Hospital Bern
View the official record on ClinicalTrials.gov →Interventions studied
DBS OFF stateDBS ON stateDopaminergic OFF drug stateDopaminergic ON drug state
What this trial is about
With this study, the investigators want to investigate whether computerized speech analysis can be used to reliably and objectively detect motor, emotional, and cognitive fluctuations in Parkinson's disease patients.
Who can take part
Age range
30 Years to 75 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Written informed consent
- Idiopathic PD according to the Movement Disorders Society Criteria;
- Age of participants \> 30 and ≤ 75 years;
- Treatment with or without bilateral deep brain stimulation in the subthalamic nucleus;
- Fluent in German or French
Exclusion criteria
- Dysarthria caused in addition by a condition other than PD (e.g. stroke, myasthenia);
- Clinical diagnosis of aphasia;
- Brain disease other than Parkinson's disease (e.g. atypical Parkinsonism, Alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, epilepsy, etc.).
- Cognitive impairment (Montreal Cognitive Assessment (MoCa) \< 24/30 points);
- Depression with acute suicidal ideation
- Healthy Controls
- Inclusion Criteria:
- Written informed consent
- Adults from 50-70 years old;
- Fluent in German or French
- Exclusion Criteria:
- Diagnosis of Parkinson's disease;
- Cognitive impairment (Montreal Cognitive Assessment (MoCa) \< 24/30 points);
- Suffering from brain disease (e.g. atypical Parkinsonism, Alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, epilepsy, etc.);
- Clinical diagnosis of aphasia, dysarthria, and stuttering;
- Suffering from or diagnosed with psychiatric illnesses according to DSM-V criteria
Where it is running
2 locations listed.
- University Hospital Inselspital, Berne - Bern, Switzerland
- Czech Technical University Prague - Prague, Czechia