Diagnosing Variable Primary Aldosteronism.
Recruiting · NCT05765786 · Observational (researchers observe without assigning treatment) · Lead sponsor: Queen Mary University of London
View the official record on ClinicalTrials.gov →What this trial is about
The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- People with clinically suspected PA but have not met criteria for diagnosis. Suspicion based on low-renin (renin activity \<0.5 nmol/h/L or renin mass \<5 ng/L), plasma sodium \> 140mmol/L or plasma potassium \< 4mmol/L.
- Patients who have been diagnosed with PA and had previous aldosterone samples \<277 pmol/L, a level which would normally not qualify for confirmatory testing.
- Patients with aldosterone results done at different times that indicate variability in production.
- Willing to consent and participate in the study.
Exclusion criteria
- Inability to withdraw β-adrenoceptor antagonist therapy for 2 weeks.
- People on end of life treatment.
Where it is running
1 location listed.
- Queen Mary University of London - London, United Kingdom