Novel MRI Techniques on Evaluation of Lymphedema
Recruiting · NCT05804643 · Observational (researchers observe without assigning treatment) · Lead sponsor: National Taiwan University Hospital
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
In this project, the investigators aim to investigate the imaging approaches for breast cancer-related secondary lymphedema. The clinical study aims to optimize the conventional MRI methods for mapping lymphedema and assess the post-surgical therapeutic effects in longitudinal follow-up studies. Additionally, a normal imaging database of lymphedema MRI images will be established for future reference. For pre-clinical animal study, investigators aim to develop and integrate two novel MRI methods, including free water elimination diffusion MRI and diffusion kurtosis MRI techniques. By integrating clinical and pre-clinical studies, the investigators aim to establish a precise imaging tool for evaluating the therapeutic effects of lymphedema for following translational applications.
Who can take part
Inclusion criteria
- adults with breast cancer related lymphedema
Exclusion criteria
- children younger than 20 years old
- pregnancy
- patients who have absolute contraindications regarding MRI scanning:
- The cardiac implantable electronic device (CIED) such as pacemakers, implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy (CRT) devices.
- Metallic intraocular foreign bodies.
- Implantable neurostimulation systems
- Cochlear implants/ear implant: bone-anchored hearing aid (BAHA) cochlear implant type can be scanned on a 1.5-tesla scanner only after the patient removes the battery. Cochlear implant wrapping scheduling must take place before the patient's MRI appointment.
- Drug infusion pumps (insulin delivery, analgesic drugs, or chemotherapy pumps): If possible, the patient has to remove the device.
- Catheters with metallic components (Swan-Ganz catheter)
- Metallic fragments such as bullets, shotgun pellets, and metal shrapnel
- Cerebral artery aneurysm clips
- Magnetic dental implants
- Tissue expander
- Artificial limb
- Hearing aid
Where it is running
1 location listed.
- National Taiwan university hospital - Taipei, Taiwan