Magnesium Prophylaxis for the Prevention of New-Onset Atrial Fibrillation in Critically Ill Patients
Recruiting · NCT05829317 · Interventional (participants receive a specific treatment) · Lead sponsor: Dr. Stephanie Sibley
View the official record on ClinicalTrials.gov →Interventions studied
Magnesium sulfatePlacebo
What this trial is about
A double-blind, multi-centre, randomized, placebo-controlled, feasibility pilot trial in the prevention of new onset atrial fibrillation of critically ill patients admitted to an ICU.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 4
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age ≥18 years;
- Admitted to an ICU with one or more of the following:
- Non-invasive ventilation (including CPAP, Bipap and high flow oxygen (\>10L/min) or invasive mechanical ventilation with an expected duration \>24 hours for respiratory failure (hypercarbic or hypoxic)
- Vasopressor or inotropic support with an expected duration of \>24 hours
- Cardiac arrest
- Continuous cardiac monitoring.
Exclusion criteria
- Receiving ICU intervention (Non-invasive ventilation (including high flow nasal canula), invasive mechanical ventilation or inotropic support) for \>18 hours
- Receiving IMV for airway protection only (for example, isolated head trauma)
- Active atrial fibrillation at the time of enrolment
- On oral or continuous infusion of Amiodarone
- Unlikely to survive \>24 hours or palliative patients
- Cardiac surgery patients
- Patients requiring parenteral magnesium therapy (e.g. pre-eclampsia, asthma)
- Patients receiving dialysis
- Positive pregnancy test (females \<50 years old)
- Previously enrolled in this trial
- Treating physician refuses enrollment
Where it is running
4 locations listed.
- St Joseph's Healthcare Hamilton - Hamilton, Ontario, Canada
- Kingston Health Sciences Centre - Kingston, Ontario, Canada
- The Ottawa Hospital - General Campus - Ottawa, Ontario, Canada
- The Ottawa Hospital - Civic Campus - Ottawa, Ontario, Canada