Exercise Response in Humans With Obesity
Recruiting · NCT05857150 · Observational (researchers observe without assigning treatment) · Lead sponsor: Mayo Clinic
View the official record on ClinicalTrials.gov →Interventions studied
Dual-Energy X-Ray AbsorptiometryFat BiopsyMagnetic resonance imagingMuscle BiopsyResting Energy ExpenditureStrength TestTreadmill Test
What this trial is about
This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.
Who can take part
Age range
20 Years to 45 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Obese men and women ≥ 20 and ≤ 45 years of age.
Exclusion criteria
- Diabetes or fasting plasma glucose \>126 mg/dL
- Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl)
- Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
- Renal failure (serum creatinine \> 1.5mg/dl)
- Chronic active liver disease defined as aspartate aminotransferase (AST)\>144 IU/L or alanine transaminase (ALT) \>165 IU/L)
- Oral warfarin group medications or history of blood clotting disorders.
- Smoking
- Pregnancy or breastfeeding
- Alcohol consumption greater than 2 glasses/day or other substance abuse
- Untreated or uncontrolled hypothyroidism
- Debilitating chronic disease (at the discretion of the investigators)
Where it is running
1 location listed across 1 US state.
- Mayo Clinic in Rochester - Rochester, Minnesota, United States