Increased Risk of Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals
Recruiting · NCT05890365 · Observational (researchers observe without assigning treatment) · Lead sponsor: Steno Diabetes Center Copenhagen
View the official record on ClinicalTrials.gov →What this trial is about
The investigators recently demonstrated a increase in liver fat in early middle-aged LBW compared to normal birth weight (NBW) men, and 20% of the LBW - but none of the normal birth weight (NBW) - men had previously unknown non-alcoholic fatty liver disease (NAFLD). Here the investigators will further examine the Increased risk of non-alcoholic fatty liver disease in low birth weight individuals by performing a validation study.
Who can take part
Age range
34 Years to 49 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- 250 healthy, men and women born with a low birth weight (birth weight (BW) \<10% of the population) and 50 born with a normal birth weight controls (BW between 50-90% of the population)
- born at term (weeks 39-41)
Exclusion criteria
- BMI\>35 kg/m2
- Disease/medication known to affect primary outcome
- Self-reported high physical activity level
- Alcohol intake above general recommendations.
- Metabolic/liver disease
- Weight gain/loss of \>3 kg within the past 6 months
Where it is running
1 location listed.
- Steno Diabetes Center Copenhagen - Herlev, Denmark