Diaphragmatic Function as a Biomarker
Recruiting · NCT05903001 · Observational (researchers observe without assigning treatment) · Lead sponsor: RWTH Aachen University
View the official record on ClinicalTrials.gov →Interventions studied
6-minute walking distance60 seconds sit-to-stand testBorg scaleCAT-QuestionnaireDiaphragm UltrasoundElectromyographyEuropean Society of Cardiology (ESC)/ European Respiratory Society (ERS) risk groupGINA classification of AsthmaIntercostal Muscle UltrasoundLung FunctionMRC Breathlessness ScaleMeasurement of respiratory mouth pressureRespiratory QuestionaireSNIP
What this trial is about
Dyspnea is among the most common symptoms in patients with respiratory diseases such as Asthma, chronic obstructive pulmonary disease (COPD), Fibrosis, and Pulmonary Hypertension. However, the pathophysiology and underlying mechanisms of dyspnea in patients with respiratory diseases are still poorly understood. Diaphragm dysfunction might be highly prevalent in patients with dyspnea and respiratory diseases. The association of diaphragm function and potential prognostic significance in patients with respiratory diseases has not yet been investigated.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- patient has one of the following lung diseases: COPD, bronchial asthma, pulmonary fibrosis, pulmonary hypertension
- is 18 years or older
- is mentally and physically able to understand the study and to follow instructions
- are legally competent
- signed declaration of consent
Exclusion criteria
- BMI \> 35
- current or treatments or diseases in the past which could influence the evaluation of the study
- Expected lack of willingness to actively participate in study-related measures
- alcohol or drug abuse
- disc herniation/prolapse
- epilepsy
- wheelchair bound
- in custody due to an official or court order
- in a dependent relationship or employment relationship with investigating physician or one of their deputy
- emergency inpatient hospital stay within 4 weeks before study-specific examinations
Where it is running
3 locations listed.
- RWTH Aachen University Hospital - Aachen, North Rhine-Westphalia, Germany
- RWTH Aachen University Hospital - Aachen, North Rhine-Westphalia, Germany
- RWTH Aachen University Hospital - Aachen, North Rhine-Westphalia, Germany