Neuroimaging of Opioid Phase (OPAL)
Recruiting · NCT05905419 · Interventional (participants receive a specific treatment) · Lead sponsor: Duke University
View the official record on ClinicalTrials.gov →Interventions studied
Opioid Phase
What this trial is about
The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.
Who can take part
Age range
18 Years and older
Sex
Female
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- for Healthy Controls:
- female and ages 18+
- ability to read/understand English and give consent to participate
- no current or history of chronic pain
- not regularly taking any pain-relieving or mood-altering medications (per PI discretion)
- absence of use of opioid medications
- Inclusion Criteria for Individuals with Chronic Pain:
- female and ages 18 +
- ability to read/understand English and give consent to participate
- self-reported or physician diagnosis of fibromyalgia and/or chronic pain
- current use of opioid medication(s) for inclusion in the opioid patient group -OR- absence of use of opioid medications for inclusion in the non-opioid patient group
Exclusion criteria
- for both groups):
- limited ability to participate fully in behavioral tasks, longitudinal follow-up
- MRI contraindication
- any factors that at the discretion of the investigators would adversely affect the participant or the integrity of the study
- male
Where it is running
1 location listed across 1 US state.
- Duke University Medical Center - Durham, North Carolina, United States