ITreatOCD: Predicting the Efficacy of Internet-based Cognitive Behavioral Therapy in Obsessive-compulsive Disorder
Recruiting · NCT05906069 · Interventional (participants receive a specific treatment)
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
In the current study, the investigators will characterize obsessive-compulsive disorder (OCD) patients and healthy controls with a comprehensive clinical and neuroimaging assessment, focusing on the basic psychological processes related and on the neurobiological underpinnings of emotion regulation (ER). After a baseline assessment, the investigators will implement an internet-based cognitive behavioral therapy (iCBT) protocol and assess its efficacy on the modulation of ER and OCD severity. Specifically, the investigators will (1) examine to what extent the iCBT intervention modulates ER and the associated neurobiological mechanisms and (2) identify candidate biomarkers of successful treatment response.
Who can take part
Inclusion criteria
- Primary diagnosis of current OCD according to the fifth Diagnostic and Statistical Manual of Mental Disorders
- YBOCS score ≥ 16
- Psychotropic medication, if stable for at least 2 months prior to inclusion and if the dosage is maintained thoughout the study
- Have the resources to access the online intervention (internet access; computer or tablet)
Exclusion criteria
- MRI contraindications
- Prior medical history of neurological disorders or traumatic brain injury
- Having performed CBT treatment for OCD in the last 2 years
- Undergoing any psychological treatment
- Suicidal ideation
- Current alcohol or drug abuse
Where it is running
1 location listed.
- Life and Health Sciences Research Institute, School of Medicine, University of Minho - Braga, Gualtar, Portugal