Cognitive Neurology Unit Clinical Registry

Inclusion criteria

• o Patient meets clinical criteria for mild cognitive impairment or early dementia from Alzheimer's disease
• Patient has evidence of cognitive impairment on neuropsychological testing
• Patient has not progressed to the moderate stage of dementia based on neuropsychological testing or clinical judgement
• Amyloid PET imaging and/or CSF analysis consistent with Alzheimer's disease
• Amyloid PET imaging positive
• CSF p-Tau/Abeta42 ration \>0.023 and ABeta42 \< 1027\*\*
• 3T MRI in past 6 months
• Patient has a care partner
• Patient under the care of an appropriate BI-Lahey amyloid clinic
• Patient is on a stable medication regimen

Exclusion criteria

• o Recent stroke or suspected TIA in the past year
• Pregnancy
• Active autoimmune or immunological disease
• Systemic treatment with immunosuppressants, immunoglobulins, or monoclonal antibodies or their derivatives
• Bleeding disorder with Plts \< 50,000 or INR \> 1.5
• On warfarin, heparin, or DOAC
• On dual antiplatelet therapy
• Non Alzheimer disease cause of dementia/MCI
• ApoE e4 homozygote