The Impact of Radiotherapy on Oligometastatic Cancer
Recruiting · NCT05933876 · Observational (researchers observe without assigning treatment) · Lead sponsor: Institut Investigacio Sanitaria Pere Virgili
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Metastases represent the most threatening challenge in cancer. One of the management strategies for patients with Oligometastatic Cancer (OC) is Stereotactic ABlative Radiotherapy (SABR). However, there are few studies, and there is no defined clinical standard, nor are the radiobiological mechanisms that contribute to treatment response well understood. The focus should be on generating evidence to guide the personalization of radiotherapy beyond solely technological and anatomical precision. This could be achieved by recollecting clinical and biological data from patients that undergo this treatment and analyzing them to ultimately predict, with the help of artificial intelligence, which patients will be the most beneficiary and improve their survival rate.
Who can take part
Inclusion criteria
- Histologic confirmation of primary tumor: breast, prostate, lung, colorectal.
- 18 years old or older.
- Up to five metastases located in the bone, lung, node, liver or brain.
- Eastern Cooperative Oncology Group (ECOG) Performance Status Scale 0 or 1.
Exclusion criteria
- Non-melanoma skin cancer.
- Previous radiotherapy in the same anatomic location.
- Presence of vascular collagen disease.
- Pregnancy or lactation at the time of inclusion.
Where it is running
21 locations listed.
- Hospital del Mar - Barcelona, Spain
- Hospital Provincial de Castellón - Castellon, Spain
- Institut Català d'Oncologia - Girona, Spain
- Hospital Universitario Ramón y Cajal - Madrid, Spain
- Hospital de Terrassa - Terrassa, Spain
- Complejo Hospitalario Universitario Albacete - Albacete, Albacete, Spain
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau - Barcelona, Barcelona, Spain
- Hospital Universitari Vall d'Hebron - Barcelona, Barcelona, Spain
- Institut Català d'Oncologia - Barcelona, Barcelona, Spain
- Hospital Universitario Virgen de las Nieves - Granada, Granada, Spain
- Hospital Universitari Arnau de Vilanova - Lleida, Lleida, Spain
- Hospital de La Luz - Madrid, Madrid, Spain
- Hospital Ruber Internacional - Madrid, Madrid, Spain
- Hospital Universitario HM Sanchinarro - Madrid, Madrid, Spain
- Hospital Universitario Quirónsalud - Madrid, Madrid, Spain
- Hospital Universitario Rey Juan Carlos - Madrid, Madrid, Spain
- Hospital Universitario Virgen Macarena - Seville, Sevilla, Spain
- Hospital Universitari Sant Joan de Reus - Reus, Tarragona, Spain
- Hospital Clínico Universitario de Valencia - Valencia, Valencia, Spain
- Hospital General Univesitario de Valencia - Valencia, Valencia, Spain
- Hospital Universitari Miguel Servet - Zaragoza, Zaragoza, Spain