Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery
Recruiting · NCT05934409 · Interventional (participants receive a specific treatment) · Lead sponsor: Université de Sherbrooke
View the official record on ClinicalTrials.gov →Interventions studied
Bariatric surgeryNicotinic Acid
What this trial is about
The present protocol aims to understand and establish whether there is a causal link between adipose tissue metabolic remodeling and Type 2 Diabetes (T2D) remission after bariatric surgery. All participants will have a bariatric surgery, divided in 2 groups: with or without T2D.
Who can take part
Age range
18 Years to 65 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Aged 18 to 65
- BMI 35 kg/m2
- Diagnosed T2D - according to Diabetes Canada diagnostics criteria.
- Diagnosed non-T2D - according to Diabetes Canada diagnostics criteria.
- Women with a negative serum pregnancy test.
Exclusion criteria
- Treatment with an oral contraceptive;
- Treatment with fibrate, thiazolidinedione, insulin, or beta-blocker, drugs that affect metabolism and cannot be stopped temporarily or which have long-lasting effects;
- Presence of overt cardiovascular disease, liver or renal failure or other uncontrolled medical conditions;
- Any other contraindication to surgery or to temporarily suspending current medications for diabetes, lipids or hypertension;
- Smoking or consumption of more than 2 alcoholic beverages per day;
- Any contraindication to MRI;
- A Diabetes Remission (DiaRem) score \>8 (low probability of T2D remission);
- Having participated to a research study with exposure to radiation in the last two years before the start of the study;
- Pregnant or breastfeeding women;
- Patients weighing more than 200 kg to respect the weight and gantry limit of our MRI and PET/CT scanners.
- Being allergic to eggs
Where it is running
1 location listed.
- centre de recherche du CHUS - Sherbrooke, Quebec, Canada